Formulation & Evaluation of Mouth Dissolving Tablets of Domperidone Using Copressed Superdisintegrants

Author

Mr. Naveen Kumar, Dr. Rajesh Sharma, Dr. Gurpreet Singh, Dr. G. Jeyabalan, Dr. Praveen Goyal

Abstract

 This research involves preparation of mouth dissolving tablets of Domperidone by direct compression method using various concentrations of co-processed superdisintegrants i.e. Sodium starch glycolate and crospovidone prepared by Microwave technology. SSG and crospovidone used in different ratio (1:1, 1:2, 1:3, 2:1, 2:2, 2:3, 3:1, 3:2 and 3:3). The tablets were evaluated for parameters like thickness, hardness, friability, In vitro & In vivo disintegration time, wetting time, water absorption ratio, % drug content and In vitro drug release studies. Based  on  the  results,  formulation  containing 6% superdisintegrants in combination (CP:SSG = 3:3) (DM-9)  was  identified  as  ideal  and  better  formulation among all formulations developed for Domperidone tablets. In vitro release of optimized formulation of Domperidone Mouth dissolving tablets (DM-9) prepared by microwave technology was found to be 99.06% drug release within 15minutes and in-vitro disintegration time being ranges between 20-23sec. Optimized formulation DM-9 showed very good stability profile. From  this observation  it was  concluded  that the  formulated  tablets of Domperidone (DM-9)  were superior, economic and  effective in  achieving patient compliance.

Keywords

Domperidone, fast dissolving, antiemetic, co-processed superdisintegrants

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